Scientific basis

Skinside (Switzerland) AG. Application study to confirm cosmetic functionality of finished products of Skinside. 2015. White Paper available on request.

Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S.. Oral intake of specific bioactive collagen peptides reduces skins wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physio2014;27(3):113-9. doi: 10.1159/000355523. Epub 2013 Dec 24.

Zague, Vivian, Vanessa de Freitas, Marina da Costa Rosa, Geórgia Álvares de Castro, Ruy G. Jaeger, and Gláucia M. Machado-Santelli. Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metalloproteinase 2 Activity. Journal of Medicinal Food. June 2011, 14(6): 618-624.doi: 10.1089/jmf.2010.0085.

Zague, Vivian, (2008). A new view concerning the effects of collagen hydrolysate intake on skin properties. Archives of Dermatological Research, vol. 300, Issue 9, 479-483.

Postlethwaite, A.E., Seyer, J.M. and Kang, A.H.( 1978). Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides. Proceedings of the National Academy of Sciences of the United States of America, Vol. 75, Iss. 2, 871-875.

Mintz, G.R., Reinhart, G.M. and Lent, B. (1991). Relationship between collagen hydrolysate molecular weight and peptide substantivity to hair. J. Soc. Cosmet. Chem., Vol 42, 35-44.

Kantor, I., Donikyan, L.A., Simon, R. And Wollschlaeger, B. (2002). Results of a study evaluating the use of a dietary supplement formula in the management of age-related skin changes in women with moderate to severe xrinkling of the periorbital area. The Journal of the American Neutraceutical Association, Vol. 5, Iss. 2, 10-19.

Chung, J., Seo, J., Choi, H., Lee, M. Young, C, Rie, G, Cho, K., Kim, K., Park, K. and Eun, H. – Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. – Am J Patrhol. 2001;158(3):931-942.

Koyama Yoichi (Nippi Res. Inst. Biomatrix, JPN) SAKASHITA ARISA (Nippi Res. Inst. Biomatrix, JPN) KUWABA KUMIKO (Nippi. Effects of oral ingestion of collagen peptide on the skin. Res. Inst. Biomatrix, JPN) KUSUBATA MASASHI (Nippi Res. Inst. Biomatrix, JPN).VOL.34;NO.6;PAGE.82-85(2006)

Ohara, H., Ichikawa, S., Matsumoto, H., Akiyama, M., Fujimoto, N., Kobayashi, T. And Tajima, S. (2010) Collagen- derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. The Journal of Dermatology, Vol. 37, Iss.4, 330-338. Yoichi, K., Arisa, S., Kumiko, K. and Masashi, K. (2006). Effects of oral ingestion of collagen peptide on the skin. Fragrance Journal, Vol. 34, Iss. 6, 82-85. Matsuda, N., Koyama, Y.-I., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., Irie, S. And Takehana, K. (2006). Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycons in the dermis. Journal of Nutrition Science and Vitaminology, Vol. 52, 211-215.

M. J. Koehler, K. König, P. Elsner, R. Bückle, and M. Kaatz – In vivo assessment of human skin aging by multiphoton laser scanning tomography. – Opt. Lett.2006; 31:879-2881.

Iwai, K., Hasegawa, T., Taguchi, Y., Morimatsu, F., Sato, K., Nakamura, Y., Higashi, A., Kido, Y., Nakabo, Y. And Ohtsuki, K. (2005). Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J. Agric. Food Chem., Vol. 53, 6531-6536.

Watanabe-Kamiyama, M., Shimizu, M., Kamiyama, S., Taguchi, Y., Sone, H., Morimatsu, F., Shirakawa, H., Furukawa, Y. And Komai, M. (2010). Absorption and effectiveness of orally administered low molecular weight collagen hydrolysate in rats. J. Agric. Food Chem., Vol. 58, 835-841.